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Critical Lessons From the ENHANCE Trial | Cardiology

    https://jamanetwork.com/journals/jama/fullarticle/181510
    A clinical end point study, known as IMPROVE-IT (Examining Outcomes in Subjects With Acute Coronary Syndrome: Vytorin [Ezetimibe/Simvastatin] vs Simvastatin), 3 was started in December 2004 and will not be available until approximately 2011, 9 …

Benefit of Adding Ezetimibe to Statin Therapy on

    https://pubmed.ncbi.nlm.nih.gov/29263150/
    Methods: In IMPROVE-IT (Improved Reduction of Outcomes: Vytorin Efficacy International Trial), 18 144 patients after acute coronary syndrome with low …

New Analysis from Investigational IMPROVE-IT Study …

    https://www.merck.com/news/new-analysis-from-investigational-improve-it-study-shows-vytorin-ezetimibe-simvastatin-reduced-total-initial-and-recurrent-cardiovascular-events-more-than-simvastatin-alone-in-patients-prese/
    Merck (NYSE: MRK ), known as MSD outside the United States and Canada, today announced results from a pre-specified exploratory analysis of the investigational …

IMProved Reduction of Outcomes: Vytorin Efficacy …

    https://www.acc.org/latest-in-cardiology/clinical-trials/2014/11/18/16/25/improve-it
    This is the first study powered for clinical outcomes to show a benefit with a nonstatin agent when added to a statin. This trial included patients who had an LDL-C of …

Vytorin Study: Disappointing Results - WebMD

    https://www.webmd.com/heart-disease/news/20080721/vytorin-study-disappointing-results
    The ENHANCE study's early results showed that Vytorin wasn't better than simvastatin alone for reducing plaque buildup in the carotid arteries, which supply blood …

Vytorin: Side effects, uses, dosage, interactions, and more

    https://www.medicalnewstoday.com/articles/vytorin
    Memory loss wasn’t reported in clinical studies of Vytorin. But simvastatin , one of the active drugs in Vytorin, is a statin . And problems with memory have been …

Vytorin and Zetia Lower Cholesterol But Do They …

    https://www.center4research.org/vytorin-zetia-lower-cholesterol-improve-health/
    Research has shown that Vytorin lowers cholesterol but most studies show it does not improve health. However, in 2014 a study funded by Merck, which makes the drug, …

Enhance Medical Study On Vytorin | Day of Difference

    https://dayofdifference.org.au/e-medical/enhance-medical-study-on-vytorin.html
    A Multicenter, Double-Blind, Randomized Study to Establish the Clinical Benefit and Safety of Vytorin (Ezetimibe/Simvastatin Tablet) vs Simvastatin Monotherapy …

Ezetimibe Added to Statin Therapy after …

    https://www.nejm.org/doi/full/10.1056/NEJMoa1410489
    Conclusions. When added to statin therapy, ezetimibe resulted in incremental lowering of LDL cholesterol levels and improved cardiovascular outcomes. Moreover, lowering …

FR: Jill Kozeny, 202/224-1308 RE: the Vytorin study

    https://www.finance.senate.gov/download/senator-grassley-asks-merck-schering-plough-additional-questions-about-vytorin-study&download=1
    to learn that after careful analysis of the ENHANCE results, medical experts are now calling Vytorin the cholesterol fighter of last resort. According to reports today on CNBC, at least …



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