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Evidence for Health Decision Making — Beyond …
- https://www.nejm.org/doi/full/10.1056/NEJMra1614394
- Although randomized, controlled trials (RCTs) have long been presumed to be the ideal source for data on the effects of treatment, other methods of obtaining evidence for decisive action are...
The importance of randomised vs non-randomised trials …
- https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(19)31111-0/fulltext
- Although randomised controlled trials (RCTs) that are rigorously designed, conducted, and analysed provide reliable and comprehensive information on the risks …
The physician’s experience of changing clinical practice: …
- https://implementationscience.biomedcentral.com/articles/10.1186/s13012-017-0555-2
- Changing clinical practice is a difficult process, best illustrated by the time lag between evidence and use in practice and the extensive use of low-value care. …
Nonrandomized Trials: Designs and Methodology
- https://onlinelibrary.wiley.com/doi/abs/10.1002/9781118445112.stat08126
- Sometimes, the nonrandomized trial study design is used, whereby participants are allocated to treatment groups using nonrandom methods. The design has …
Pragmatic clinical trials: Testing treatments …
- https://www.nia.nih.gov/research/blog/2017/06/pragmatic-clinical-trials-testing-treatments-real-world
- In an explanatory trial, participants may be randomized in the order that they are recruited. In …
Pragmatic Trials | NEJM
- https://www.nejm.org/doi/full/10.1056/NEJMra1510059
- Luce BR, Kramer JM, Goodman SN, et al. Rethinking randomized clinical trials for comparative effectiveness research: the need for transformational …
Top 10 Clinical Trials That Went Horribly …
- https://listverse.com/2017/06/19/top-10-clinical-trials-that-went-horribly-wrong/
- 2John Hopkins Asthma Trial Ellen Roche, a technician at Johns Hopkins Hospital, volunteered to take part in an asthma trial for healthy individuals. The trial’s …
Non Randomized Trials That Changed Medical Practice
- https://dayofdifference.org.au/n-medical/non-randomized-trials-that-changed-medical-practice.html
- Objectives: To assess the value of advanced statistical methods in the process of estimating differences between a complementary and a conventional …
When are randomised trials unnecessary? Picking signal …
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1800999/
- Although parallel group randomised trials will remain the principal means of obtaining reliable evidence about the average effects of treatments when effects are …
7 Clinical Trials That May Change Your Practice | Consultant360
- https://www.consultant360.com/exclusive/infectious-diseases/viral-infections/7-clinical-trials-may-change-your-practice
- Avery RK. 7 clinical trials that may change your practice [published online October 16, 2019]. Infectious Diseases Consultant. During my session at IDWeek 2019, I discussed 6 …
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