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Discoveries in Medicine -Novel Arteriovenous Coupler …

    https://discoveries.vanderbilthealth.com/2019/01/novel-arteriovenous-coupler-therapy-for-hypertension-enters-us-trial/
    The ROX Coupler is a stent-like, nitinol device with shape memory to self-expand on deployment. When placed using femoral vein and arterial access, the coupler may help lower BP by decreasing total volume of blood in the arterial circulation, thereby decreasing peripheral vascular resistance.

Midterm complications of ROX arteriovenous coupler …

    https://pubmed.ncbi.nlm.nih.gov/32974488/
    The ROX arteriovenous coupler (ROX, Medical Inc., San Clemente, CA, USA), initially developed for treatment of chronic obstructive pulmonary disease, exploits …

Considering a New Approach to Treatment of

    https://evtoday.com/articles/2018-sept/considering-a-new-approach-to-treatment-of-uncontrolled-hypertension-with-the-rox-coupler-device
    The ROX Coupler has a unique dual mechanism of action that targets both mechanical and neurohormonal causes of hypertension. In contrast to other device therapies for hypertension, the ROX Coupler is designed to cause …

Central arteriovenous anastomosis for the treatment of …

    https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(14)62053-5/fulltext
    The ROX CONTROL HTN study is an international, open-label, multicentre, prospective, randomised, controlled trial investigating …

The ROX coupler: Creation of a fixed iliac arteriovenous …

    https://onlinelibrary.wiley.com/doi/full/10.1002/ccd.25707
    The ROX coupler is a novel technology designed to reduce arterial blood pressure consequent to the predicted physical effects of reducing vascular resistance and …

Novel therapy for uncontrolled high blood pressure studied

    https://feinstein.northwell.edu/news/the-latest/novel-therapy-for-uncontrolled-high-blood-pressure-studied
    The ROX Coupler and FLOW procedure being tested in the trial creates a passage between an artery and a vein in the pelvis, which redirects a measured amount …

Midterm complications of ROX arteriovenous coupler …

    https://academic.oup.com/ehjcr/article/4/4/1/5880209
    Background. Resistant and uncontrolled hypertension prominently amplifies the risk of end-stage renal disease and fatal cardiovascular events. Therapeutic inertia, …

The Coupler - New Implant Lowers Blood Pressure …

    https://www.science20.com/news_articles/the_coupler_new_implant_lowers_blood_pressure_after_outpatient_procedure-152542
    A new device developed by ROX Medical and named the 'Coupler' is a paper clip-sized implant which is inserted between the artery and vein in the upper thigh that has been shown to significantly lower …

ROX Medical CONTROL HTN-2 Clinical Trial; First …

    https://www.prnewswire.com/news-releases/rox-medical-control-htn-2-clinical-trial-first-procedure-performed-300531158.html
    The ROX CONTROL HTN-2 Clinical Trial will evaluate the ROX Coupler therapy’s ability to lower uncontrolled blood pressure. New therapies such as the ROX Coupler may offer patients an...

A Multicenter Study to Evaluate the ROX Coupler in …

    https://clinicaltrials.gov/ct2/show/NCT02895386
    To evaluate the safety and effectiveness of the ROX Coupler used to create an arteriovenous anastomosis in the iliac region (between the iliac artery and vein) in …



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