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Trifluoromethyl group - Wikipedia
- https://en.wikipedia.org/wiki/Trifluoromethyl_group
- The trifluoromethyl group is a functional group that has the formula -CF3. The naming of is group is derived from the methyl group (which has the formula -CH3), by replacing each hydrogen atom by a fluorine atom. Some common examples are trifluoromethane H–CF 3, 1,1,1-trifluoroethane H 3C–CF 3, and … See more
Trifluoromethyl Group - an overview | ScienceDirect Topics
- https://www.sciencedirect.com/topics/chemistry/trifluoromethyl-group
- The introduction of trifluoromethyl groups into organic molecules can dramatically change their physical properties and biological activity, and trifluoromethylated …
Processes | Free Full-Text | FDA-Approved …
- https://www.mdpi.com/2227-9717/10/10/2054
- In medicinal chemistry, TFM is commonly used to replace the methyl group. In comparison to other alkyl groups, the -CF 3 group has a substantially higher …
The trifluoromethyl group in medicinal chemistry - PubMed
- https://pubmed.ncbi.nlm.nih.gov/13665284/
- The trifluoromethyl group in medicinal chemistry The trifluoromethyl group in medicinal chemistry J Med Pharm Chem. 1959 Apr;1(2):121-33.doi: …
The trifluoromethyl group in medicinal chemistry.
- https://www.semanticscholar.org/paper/The-trifluoromethyl-group-in-medicinal-chemistry.-Yale/8e4290b1ab55f00a3e9fa9048be648f86e09253b
- The review covers the detailed chemistry of 19 FDA-approved drugs in the past 20 years, which contains the TFM group as one of the pharmacophores, and details the previous …
N-Trifluoromethyl Amines and Azoles: An Underexplored …
- https://pubmed.ncbi.nlm.nih.gov/33112606/
- Introducing trifluoromethyl groups is a common strategy to improve the properties of biologically active compounds. However, N-trifluoromethyl moieties on …
Trifluoromethylation - an overview | ScienceDirect Topics
- https://www.sciencedirect.com/topics/chemistry/trifluoromethylation
- Trifluoromethylation reactions have attracted a great deal of attention in recent years, as this methodology provides access to several fluorinated compounds which have great …
The Trifluoromethyl Group as a Bioisosteric …
- https://pubs.acs.org/doi/10.1021/acs.jmedchem.9b00252
- The Trifluoromethyl Group as a Bioisosteric Replacement of the Aliphatic Nitro Group in CB1 Receptor Positive Allosteric Modulators | Journal of Medicinal …
The trifluoromethyl group in medicinal chemistry.
- https://europepmc.org/article/MED/13665284
- The trifluoromethyl group in medicinal chemistry. H L YALE Search articles by 'H L YALE' YALE HL Journal of Medicinal and Pharmaceutical Chemistry, 01 Apr 1959, …
The Trifluoromethyl Group as a Bioisosteric …
- https://abdn.pure.elsevier.com/en/publications/the-trifluoromethyl-group-as-a-bioisosteric-replacement-of-the-al
- The Trifluoromethyl Group as a Bioisosteric Replacement of the Aliphatic Nitro Group in CB1 Receptor Positive Allosteric Modulators (PAMs) — The University of Aberdeen …
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