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Trifluoromethyl group - Wikipedia

    https://en.wikipedia.org/wiki/Trifluoromethyl_group
    The trifluoromethyl group is a functional group that has the formula -CF3. The naming of is group is derived from the methyl group (which has the formula -CH3), by replacing each hydrogen atom by a fluorine atom. Some common examples are trifluoromethane H–CF 3, 1,1,1-trifluoroethane H 3C–CF 3, and … See more

Trifluoromethyl Group - an overview | ScienceDirect Topics

    https://www.sciencedirect.com/topics/chemistry/trifluoromethyl-group
    The introduction of trifluoromethyl groups into organic molecules can dramatically change their physical properties and biological activity, and trifluoromethylated …

Processes | Free Full-Text | FDA-Approved …

    https://www.mdpi.com/2227-9717/10/10/2054
    In medicinal chemistry, TFM is commonly used to replace the methyl group. In comparison to other alkyl groups, the -CF 3 group has a substantially higher …

The trifluoromethyl group in medicinal chemistry - PubMed

    https://pubmed.ncbi.nlm.nih.gov/13665284/
    The trifluoromethyl group in medicinal chemistry The trifluoromethyl group in medicinal chemistry J Med Pharm Chem. 1959 Apr;1(2):121-33.doi: …

The trifluoromethyl group in medicinal chemistry.

    https://www.semanticscholar.org/paper/The-trifluoromethyl-group-in-medicinal-chemistry.-Yale/8e4290b1ab55f00a3e9fa9048be648f86e09253b
    The review covers the detailed chemistry of 19 FDA-approved drugs in the past 20 years, which contains the TFM group as one of the pharmacophores, and details the previous …

N-Trifluoromethyl Amines and Azoles: An Underexplored …

    https://pubmed.ncbi.nlm.nih.gov/33112606/
    Introducing trifluoromethyl groups is a common strategy to improve the properties of biologically active compounds. However, N-trifluoromethyl moieties on …

Trifluoromethylation - an overview | ScienceDirect Topics

    https://www.sciencedirect.com/topics/chemistry/trifluoromethylation
    Trifluoromethylation reactions have attracted a great deal of attention in recent years, as this methodology provides access to several fluorinated compounds which have great …

The Trifluoromethyl Group as a Bioisosteric …

    https://pubs.acs.org/doi/10.1021/acs.jmedchem.9b00252
    The Trifluoromethyl Group as a Bioisosteric Replacement of the Aliphatic Nitro Group in CB1 Receptor Positive Allosteric Modulators | Journal of Medicinal …

The trifluoromethyl group in medicinal chemistry.

    https://europepmc.org/article/MED/13665284
    The trifluoromethyl group in medicinal chemistry. H L YALE Search articles by 'H L YALE' YALE HL Journal of Medicinal and Pharmaceutical Chemistry, 01 Apr 1959, …

The Trifluoromethyl Group as a Bioisosteric …

    https://abdn.pure.elsevier.com/en/publications/the-trifluoromethyl-group-as-a-bioisosteric-replacement-of-the-al
    The Trifluoromethyl Group as a Bioisosteric Replacement of the Aliphatic Nitro Group in CB1 Receptor Positive Allosteric Modulators (PAMs) — The University of Aberdeen …



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